DMPS-TEST

DMPS-test

A test to measure total heavy metal body burden. 

DMPS is a chelator and stands for a sodium salt of 2,3 Di-Mercapto-1-Propane-Sulphonic acid.  This means that DMPS can bind certain substances like heavy or toxic metals, including mercury and lead.  As wel as certain minerals including zinc, copper and iron. DMPS can also release these substances from body depots. It is therefore used to detoxify the body of mercury and lead. [1]
DMPS is absorbed into the body and (in particular) excreted via the urine. The maximum concentration in the blood is reached after 30 to 50 minutes. The maximum excretion of the metals / minerals with the urine is achieved after 2 to 3 hours. With the substances that it binds to it, the DMPS forms a stable water-soluble complex.

In the DMPS test the mentioned properties of DMPS are used to determine the body's load with mercury. The amount of mercury excreted with the urine after intake of DMPS has been found to be a good measure for the body load with mercury.1 The DMPS test indicates (in addition to the concentration of mercury in the urine) the amount of mercury per gram of creatinine in the urine. Creatinine is excreted in the urine at a relatively constant rate that is independent of the amount of urine produced. The amount of mercury per gram of creatinine is a better measure than the mercury concentration in the urine (ppb) because the amount of mercury per gram of creatinine is not affected by the amount of urine produced.
In order to obtain the best possible impression of the body's load with mercury, the amount of mercury in two samples is determined: a sample of the morning urine (from before the intake of the DMPS capsule, the basic value). And a urine sample of 2-3 hours after the intake of the DMPS capsule. The mercury value of this last sample gives an impression of the amount of mercury in the body depots compared to the morning urine sample.

Because DMPS can also bind nutrients from the diet (and even has a greater affinity for zinc and copper than for mercury), it is important that the DMPS capsule is taken on an empty stomach immediately after the morning urine sample has been identified. When the DMPS binds minerals from the diet, it can bind less mercury, so that the measured value can be too low.

When is it meaningful to perform the DMPS-test?

It can be useful to do the DMPS-test when there is a suspicion of a mercury tax.

A mercury tax can play a role in the following disorders: 2,3
• Anemia (anemia)
• Anorexia
• High bloodpressure
• Depression
• Problems with the Memory
• Irritation / moodiness
• Headache
• Skin problems
• Gastrointestinal problems / Diarrhea
• Insomnia
• Inflamed gums
• Fatigue
• Fertility problems
• Reduced resistance

COMPLEMENTARY TESTS:

  • (trace) elements in blood. The sensitivity of people to mercury differs. The status of the nutrients involved in the detoxification of mercury, in particular those of the trace element selenium, can play a role in this. Measuring the status of these nutrients is therefore also useful.
  • Mercury in saliva test. The DMPS test provides information about the body's load with mercury in general. The mercury can come from different sources. When there is a need to check the specific load via the amalgam fillings, the mercury can be put into saliva. This test specifically measures the body's load with mercury through the fillings.
  • MELISA test :: the Melisa test verifies the (hereditarily determined) immunological (over) sensitivity of persons for a range of metals / substances (2 packages are available) many of which are used in dental / medical practice (including various mercury compounds) ). Through this test, immunological reactions to mercury and other metals / substances used in the dental / medical practice can be checked. Such a reaction can occur with the substance in question and cause complaints at a relatively low (non-toxic) load.

LITERATURE:

  1.  Cerian et al. Estimation of mercury burden in rats by chelation with dimercaptoprocane sulphate; J. Pharmacol. Exo. Ther. 1988:245, 479-84.
  2. M. Godfrey et al. Confirmation of Mercury retention and toxicity using 2,3-dimercapto-1-propane-sulphonic acid sodium salt (DMPS); J. Adv. Med. Vol 7 (no 1), spring 1994: 19-30
  3. M.R. Werbach. Nutritional Infuences on Illness. A sourcebook of clinical research. Second edition, Third Line Press, Tarzana, California.,1993.
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